The following article lists the settings that require Strategy Intelligence Server 2021 to be restarted in order for the changes to take effect.
Server-level settings
At the server level, only a few settings from each category need a server restart. These are outlined below:

Server Definition
General
Advanced
Statistics
General
Governing
Default
General
Memory Settings
Working Set
Projects
General
History Settings
General
Project-level settings
Only a few settings require a server restart for the changes to take effect. These are outlined below:

Database instances
Statistics
Caching
Result Caches
Auxiliary Caches
Objects
Element cache
Intelligent Cubes
General
Security filter
General
Important Notes:
KB26144