In Strategy 10.x, when attempting to connect to Salesforce using the Strategy ODBC driver for Salesforce , the following error is received:
2013-04-09 15:21:48.617-06:00 Failed to connect to data source. Error message: Connect failed. Error type: Odbc error. Odbc operation attempted: SQLDriverConnect. java.net.ConnectException: Connection refused: connect Connection String: DSN=SALESFORCE_TEST; UID=ABC@ABC.NET

Refer to the following article from Data Direct for more information: http://knowledgebase.datadirect.com/articles/Article/000036226?retURL=%2Fapex%2FKnowledgeSearch&popup=false
On UNIX/Linux operating systems, edit the odbc.ini file found in the Strategy home folder and add the following parameters to the Salesforce DSN.
ProxyHost= ProxyPassword= ProxyPort= ProxyUser=